胃肠肽VIP及NPY的变化与肠易激综合征间关系

张红杰 林琳 阎验 林征 王美峰 赵志泉 2005-12-13 12:57:51 中华现代内科学杂志 2004年9月第1卷第2期

　　【摘要】 目的 研究肠易激综合征（IBS）患者血浆、乙状结肠黏膜组织中VIP及NPY的含量变化与肠易激综合征发病间的关系。方法 用放射免疫法分别检测IBS患者（40例）和正常对照组（15例）血浆及乙状结肠黏膜组织中血管活性肠肽（VIP）、酪神经肽（NPY）的含量。结果 （1）与正常对照组相比，IBS患者肠黏膜组织中VIP含量升高（P<0.01），NPY减低（P<0.05）。（2）与正常对照组相比，IBS患者血浆NPY含量减低（P<0.05），而VIP含量变化差异无显著性（P>0.05）。结论 IBS患者乙状结肠黏膜中VIP、NPY的变化在IBS的发病中有一定的作用。

　　关键词 肠易激综合征 酪神经肽 血管活性肠肽 胃肠运动 黏膜 

　　Relationship between VIP，NPY and irritable bowel syndrome   Zhang Hongjie，Lin Lin，Yan Yan，et al.

　　The Department of Gastroenterology，the First Affiliated Hospital of Nanjing Medical University，Jiangsu210029.

　　【Abstract】 Objective To investigate the alteration and clinical significance of vasocative intestinal polypeptide（VIP），neuropeptide tyrosine（NPY）in irritable bowel syndromeIBS）.Methods The levels of VIP，NPY in plasma and sigmoid mucosa were measured by radioimmunoassay（RIA）in normal group（n=15）and IBS group（n=40）.Results The level of VIP in the sigmoid mucosa in IBS group was significantly higher than that in the normal groupP<0.01），and there was no significant differences between two groups in the plasma VIPP>0.05）.The levels of NPY in the plasma and sigmoid mucosa in IBS group were significantly lower than that in the normal group（P<0.05）.Conclusion The alteration of these gastrointestinal hormones in plasma and sigmoid mucosa may play some role in the pathogenesis of IBS.Key words irritable bowel syndrome VIP，NPY gastrointestinal motility plasma sigmoid mucosa