左旋氨氯地平对麻醉开胸犬血流动力学和氧代谢的影响
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吕文伟 李 红 石 卓 杨世杰 2005-12-13 13:07:21 中华中西医杂志 2003年8月第4卷第15期 关键词 左旋氨氯地平 血流动力学 氧代谢 钙拮抗剂 The influence of L-amlodipine on hemodynamics and oxygen metabolism of anethetic thoraco-opening dog Lu Wenwei，Li Hong，Shi Zhuo，et al. Department of Pharmacology，School of Basic Medical Science，Jilin University，Changchun130021. 【Abstract】 Objective To observe the influence of L-amlodipine on hemodynamics and oxygen metabolism of anethetic thoraco-opening dog.Methods Administrate relatively L-amlodipine with the dosage of0.08mg/kg，0.16mg/kg and0.32mg/kg and record all the data of hemodynamics and oxygen metabolism.Results L-amlodipˉine can increase cardiac output（CO）and myocardial blood flux（CBF），decrease coronary resistance（CR）and oxygen consumption of myocardium.Statistcal difference is marked compared with control group.It can also influence left venˉtricle working index（LVWI），totle peripheral vessel resistance（TPVR）.Conclusion L-amlodipine can clearly acˉcommodate and ameliorate heart function of the anethetic thoraco-opening dog.
【摘要】 目的 探讨左旋氨氯地平对麻醉开胸犬血流动力学和氧代谢的影响。方法分别给予左旋氨氯地平0.08mg/kg、0.16mg/kg、0.32mg/kg，观察左旋氨氯地平对麻醉开胸犬血流动力学和氧代谢各项指标的作用。结果 经十二指肠给予左旋氨氯地平，增加心排出量（CO）及心肌血流量（CBF），降低冠脉阻力（CR）及心肌耗氧量。与生理盐水对照组比较，具有明显统计学意义。对左室作功（LVWI）、总外周阻力（TPVR）等亦具有一定作用。结论 左旋氨氯地平对麻醉开胸犬心脏功能有明显调节和改善作用。