低分子量肝素对肾病综合征病人t-PA与D-D的影响

李丽慧 曲宁 刘意 谭庆杰 范妮娜 2005-12-13 13:08:35 中华中西医杂志 2003年4月第4卷第7期

摘要】 目的 探讨低分子量肝素（LMWHs）的溶栓作用。方法 用底物显色法和ELISA法测定肾病综合征（NS）病人应用LMWHs前后血浆组织纤溶酶原激活剂（t-PA）与D-二聚体（D-D）水平。结果 皮下注射LMWHs后血浆t-PA与D-D水平明显增高，而静脉滴注LMWHs血浆t-PA与D-D水平无明显变化。结论 皮下注射LMWHs有明显的溶栓作用。

关键词 肾病综合征 低分子量肝素 组织纤溶酶原激活剂 D-二聚体 

Effect of LMWHs on t-PA and D-D in patients with nephrotic syndrome 

Li Lihui，Qu Ning，Liu Yi，et al. 

The2nd Affiliated Hospital of Shenyang Medical College，Liao Ning110002. 

【Abstract】 Objective To investigate promoting thrombolysis of low molecular weight heparin（LMWHs）.Methods level of tissue plasminogen activitor（t-PA）and D-Dimer（D-D）were measured by chromogenic subˉstrate method and ELISA method in patients with nephrotic syndrome（NS）after using LMWHs.Results Level of t-PA and D-D were increased significantly in subcutaneous injection（I.H），yet，the level of them were not significant difference in intravenous drip（I.V）.Conclusion LMWHs subcutaneous infection has significantly effect of promoting thrombosis.

Key words nephrotic syndrome low molecular weight heparins tissue plasminogen activitor D-Dimer 

高凝状态是肾小球疾病，尤以肾病综合征（NS）为多见，表现为血浆凝血因子和血小板增多，抗凝血酶Ⅲ（AT-Ⅲ）和纤溶酶原（PLG）降低 ^［1］ 。因此，血液凝固性增高，肾小球内有纤维蛋白沉积或微血栓形成。临床上多采用抗凝，促纤溶和抗